WebDec 1, 2024 · Background: Genome-wide association studies have identified multiple risk variants for psychiatric disorders. Nevertheless, how the risk variants confer risk of … WebBrain proteome-wide association study implicates novel proteins in depression pathogenesis. adriana lori. 2024, Nature Neuroscience. See Full PDF Download PDF.
Large-scale plasma proteomic analysis identifies proteins …
WebJun 23, 2024 · Methods: We systematically integrated lacunar stroke genome-wide association study (GWAS) (N=7338) with human brain proteomes (N=376) to perform proteome-wide association studies (PWAS), Mendelian randomization (MR), and Bayesian colocalization. We also used an independent human brain proteomic dataset … WebDec 1, 2024 · In this study, we performed proteome-wide association studies ... In addition, Wingo et al. also conducted a validation study using the brain proteome from … top website builders for designers
Identifying causal genes for stroke via integrating the proteome …
WebJan 28, 2024 · This work integrated AD GWAS results with human brain proteomes to perform a proteome-wide association study (PWAS) of AD, followed by Mendelian randomization and colocalization analysis and identified 11 genes that are consistent with being causal in AD, acting via their cis-regulated brain protein abundance. Genome … WebDec 7, 2024 · Utilizing a two-stage proteome-wide association study (PWAS) design, MS GWAS data (N = 41,505) was respectively integrated with two distinct human brain … WebApr 22, 2024 · Methods: Utilizing multidimensional high-throughput data generated, we integrated proteome-wide association study (PWAS), transcriptome-wide association study (TWAS), Mendelian randomization (MR), and Bayesian colocalization analysis to prioritize genes that contribute to stroke and its subtypes risk via affecting their … top website builder small business